Smith published the name Z. zerumbet in Part 2 of Exotic Botany , which was published sometime between 1 December 1805 and 1 January 1808. Increase Appetite. The results demonstrate increased local iNOS activity in TNB-Induced colitis mimicking the situation in human inflammatory bowel disease. Zingiber ovoideum Blume. Multiple reviews demonstrating the pharmacological effects of zerumbone for various diseases have been published. The anticancer effect of sesquiterpene lactones and their molecular mechanism are reviewed by Zhang et al. They are widely distributed among flowers, fruits, and vegetables. The flavonoid component showed the strongest inhibition of aldose reductase, compared with sesquiterpene component. A natural compound, zerumbone was extracted, isolated and purified from the rhizomes of edible plant Zingiber zerumbet using methanol extraction and Column Chromatography (CC) method. found that normal colon fibroblasts were not harmful compared with cancer cells once treated with Zerumbone at 50 μM for 72 hours. A profound and sustained increase in the activity of iNOS was found in the colon. ((Cancer Cell International, April 3, 2007). Its effects - when taken in concert with prescription drugs, over-the-counter drugs, and/or illegal drugs - are unknown. The immunoreactivity in the synovial membranes was evaluated with the aid of immunohistochemistry (IHC) study using the immunoflourescence technique. Results from ozonolysis, and base-catalysed cleavage allowed the compound to be formulated as 2,6,9,9-tetramethyl-2,6,10-cyclo-undecatrien-1-one. Zerumbone (ZER), a sesquiterpene from the edible plant Zingiber zerumbet Smith, has recently been found to suppress tumor promoter 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein–Barr virus activation in a potent manner.In the present study, we evaluated the anti-inflammatory and chemopreventive potentials of ZER in a variety of cell culture experiments. Zerumbone (ZER) has low aqueous solubility. 8). Evaluation of OA changes following 4 weeks of treatment was done through macroscopic and microscopic examinations supported with radiography to the knee joints. Exposure of RL34 cells to ZER resulted in the significant induction of glutathione S-transferase, while the reduced analogues of ZER (alpha-humulene and 8-hydroxy-alpha-humulene) did not show any inducing effect. Approximately 75% of the world population relies on traditional therapies and therefore there has been a growing interest in the utilization of natural compounds. Zerumbone is a natural product found in the gingers Zingiber aromaticum and Zingiber zerumbet. Among forced-flow layer chromatographic techniques, the centrifugally-driven variety was first developed, and named centrifugal layer chromatography, in 1947 by Hopf. Zingiber zerumbet extracts are used for treatment of fever, severe sprains, headaches, asthma, indigestion, diarrhoea, constipation, inflammation, toothache, oedema, worm infestation in children [82], leukemic cancer, lung carcinogenesis, skin tumour, hepatocarcinogenesis, colon and cervical intra epithelial neoplasia. Metabolic engineering (indicated by blue gear wheels) enables biosynthesis of desired products. taiwaniana by centrifugal partit... Cytotoxic Components from the Dried Rhizomes of, Extraction and Identification of an Antioxidative Component from Jue Ming Zi (Cassia tora L.). It has been extensively investigated for antitumor, anti-proliferative and apoptotic activity. Besides ginger, zerumbone (a sesquiterpene) derived from a subtropical ginger Zingiber zerumbet Smith was also reported to have antitumor and anti-inflammatory properties in different cancers. Zerumbone (ZER), a monosesquiterpene found in the subtropical ginger (Zingiber zerumbet Smith), possesses antiproliferative properties to several cancer cells lines, including the cervical, skin and colon cancers. Zerumbone was found to possess immunomodulatory activity via modulation of MAPK and NFкB pathways [132] as well as cytokines production [133]. The recombinant strain was deficient in PHB synthesis and previously engineered by Grousseau et al. Cancer . Zingiber aromaticum Valeton, (1918), Amomum zerumbet L.) est une plante herbacée du genre Zingiber de la famille des Zingiberaceae originaire d'Asie.. Ses noms communs en français sont: Amome sauvage, Zérumbet, ou encore Gingembre shampooing [2].Il est connu au Cambodge sous le nom de phteu (ផ្ទឺ) [2].. Sa vigoureuse tige feuillue peut atteindre 1,20 de haut. The leaves of the plant are used as a food additive and wrapping material. Sharada H. Sharma, ... Sangeetha Nagarajan, in European Journal of Pharmacology, 2017. Compounds 1-6 were evaluated for inhibition of the transformation of murine epidermal JB6 cells, inhibition of ornithine decarboxylase induction with murine epidermal ME 308 cells, and cytotoxic activity against KB cells. used a bioelectrochemical cell that employs, instead of rare platinum, earth-abundant metals for water splitting at low overpotential. Zingiber Zerumbet-Smith is a "folk remedy." Zerumbone was initially isolated from the rhizome of a subtropical wild shampoo ginger (Zingiber zerumbet Smith) and was determined to be an anti-inflammatory agent. Monolayers of immortalized ovarian cancer cell lines and primary ovarian cancer cells obtained from ascites were grown in the presence of cisplatin, 4-hydroxyperoxy-cyclophosphamide (the active metabolite of cyclophosphamide) or paclitaxel. [citation needed] Indigenous Practices Areeful Haque, in, Complexation of phytochemicals with cyclodextrin derivatives – An insight, Vasanti Suvarna, ... Manikanta Murahari, in, Biocatalysis and Biotransformation ● Bioinorganic Chemistry, Terpenoids as anti-colon cancer agents – A comprehensive review on its mechanistic perspectives, Sharada H. Sharma, ... Sangeetha Nagarajan, in. This study showed promising avenues towards zerumbone to be developed as a new chemo-natural drug for treatment of cervical cancer. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Medicinal Properties of Zerumbone: suppresses free radical generation; anti-inflammatory; Ovarian cancer cell death in response to commonly used chemotherapeutic drugs involves the induction of a genetically programmed sequence of events (apoptosis) rather than simply necrosis. The cell death machinery is evolutionarily conserved and composed of caspases and their regulatory components that include activators and repressors. Smith published the name Z. zerumbet in Part 2 of Exotic Botany , which was published sometime between 1 December 1805 and 1 January 1808. The ketone has been shown to be monocyclic containing three ethylenic linkages, and has been further correlated with humulene. Introduction. Journal of Agricultural and Food Chemistry. Five week dietary supplementation of zerumbone to AOM induced colon cancer rats caused a 14% reduction in ACF frequency at a dose of 0.01% whereas 45% reduction was achieved at a dose of 0.05%. Join ResearchGate to find the people and research you need to help your work. We use cookies to help provide and enhance our service and tailor content and ads. The concentrations of the prostaglandins were determined during three periods that is before and during OA periods and after 4 weeks of the treatment. No increases in plasma nitrite + nitrate concentrations were found suggesting local rather than systemic induction of iNOS. Of the eight fractions, fraction V possessed significant antioxidant activity and showed 85.8% inhibition on peroxidation of linoleic acid. Zerumbone is currently being explored for its effects on cancer in general and leukemia in particular. However, the material ratio only gave significant effect on the zerumbone concentration and less significant on the yield. taiwaniana. Among these anthocyanins, kuromanin (cyanidin-3-glucoside) had the highest ORAC activity, which was 3.5 times stronger than Trolox (vitamin E analogue), while pelargonin had the lowest antioxidant activity but was still as potent as Trolox. Investigations done so far clearly depicts SLs as emerging as well as promising anti-colon cancer agents, but further studies are needed to explore the molecular mechanisms in depth to develop SLs as potential dietary anticancer agents with respect to colon cancer. This paper summarizes the classifications and applicability of versions of this technique. It has antimicrobial, antinociceptive, antiatherosclerotic, hepatoprotective and antioxidant properties. An ethyl acetate-soluble extract of the combined leaves and twigs of Thuja occidentalis was found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) in cultured mouse epidermal ME 308 cells. Most well-known natural compounds are polyphenols, flavonoids, and terpenes [26]. The anticancer properties of zerumbone (2,6,9 humulatriene-8-one, a sesquiterpenoid) from Zingiber aromaticum were compared with those of curcumin from Curcuma longa in an in vitro MTT tetrazolium salt assay using HT-29, CaCo-2, and MCF-7 cancer cells and in an azoxymethane (AOM)-induced animal model of colon cancer using aberrant crypt foci (ACFs) as a preneoplastic marker. Cancer . We recently showed that zerumbone, a sesquiterpene found in subtropical ginger, suppresses colonic tumor marker formation in rats and induces apoptosis in colon cancer cell lines. Zerumbone is a sesquiterpene phytochemical from a type of edible ginger known as China Zingiber Zerumbet Smith grown in South China or "Zingiber aromaticum". Compounds are polyphenols, flavonoids, and named centrifugal layer chromatography, in European Journal of planar.... 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